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The World Trade Organization’s director-general Roberto Azevedo steps down on Monday, leaving the already-damaged global watchdog leaderless as it faces the biggest crisis in its 25-year history.

“This is indeed a new – though alas not unsurprising – low point for the WTO,” said Rohinton Medhora, president of the Centre for International Governance Innovation. “The organisation has been directionless for some time, several years in fact, and will now be functionally leaderless.”

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